Substance
ID:349967
Names and Identifiers
IUPAC name
2-amino-2-(hydroxymethyl)propane-1,3-diol
IUPAC Traditional name
tris buffer
Synonyms
2-Amino-2-(hydroxymethyl)-1,3-propanediolTrometamolTHAMTris base2-氨基-2-(羟甲基)-1,3-丙二醇Tris 碱氨基丁三醇三羟甲基氨基甲烷Trizma® baseTrizma® 碱Tris(hydroxymethyl)aminomethane
Registration numbers
CAS Number
MDL Number
EC Number
Beilstein Number
PubChem SID
Properties
Physical Property
p𝘒ₐ
8.1 (25°C)
Boiling Point
219-220 °C/10 mmHg(lit.)
Melting Point
167-172 °C(lit.)
Safety Information
GHS Precautionary statements
P261-P305+P351+P338
German water hazard class
2
European Hazard Symbols
Irritant (Xi)GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
MSDS Link
GHS Signal Word
Warning
Safety Statements
26-36
GHS Hazard statements
H315-H319-H335
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Risk Statements
36/37/38
RTECS
TY2900000
Product Information
Grade
Biotechnology Performance Certified
Linear Formula
NH2C(CH2OH)3
Suitability
meets EP, USP testing specifications
cell culture tested
Useful pH Range
7 - 9
Cation Traces
heavy metals (as Pb): ≤2 ppm
Impurities
DNase, RNase, protease, none detected
Endotoxin and Total Count Aerobic, Yeast, plus Mold, tested
≤0.2% water (Karl Fischer)
abs.
A40%/290 ≤0.05
Purity
≥99.9% (titration)
Quality Level
ELITE
Description
aminopeptidase substrate
Molecule Details
Application
Not tested for use in parenteral applications as specified in the EP monograph.
Other Notes
Easily compare specifications for Trizma products with the Trizma specification table.
The pH values of all buffers are temperature- and concentration-dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution.For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.
Legal Information
Trizma is a registered trademark of Sigma-Aldrich Co. LLC
Not tested for use in parenteral applications as specified in the EP monograph.
Other Notes
Easily compare specifications for Trizma products with the Trizma specification table.
The pH values of all buffers are temperature- and concentration-dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution.For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.
Legal Information
Trizma is a registered trademark of Sigma-Aldrich Co. LLC
Molecular Spectra
No Data Available
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References
No Data Available
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