Substance
ID:349539
Names and Identifiers
IUPAC Traditional name
ethyl 4-chloro-1-methyl-2-oxoquinoline-3-carboxylate
IUPAC name
ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
Synonyms
4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl esterEthyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylateAI-1
Properties
Safety Information
GHS Hazard statements
H317
European Hazard Symbols
Irritant (Xi)Risk Statements
43
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Safety Statements
36/37
MSDS Link
GHS Signal Word
Warning
Storage Temperature
2-8°C
GHS Precautionary statements
P280
Product Information
Purity
≥98% (HPLC)
Empirical Formula (Hill Notation)
C13H12ClNO3
Physical Property
Solubility
DMSO: ≥15 mg/mL
Apperance
white to tan powder
Molecule Details
Biochem/physiol Actions
AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.
AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.
Molecular Spectra
No Data Available
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References
No Data Available
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