Substance
ID:311845
Names and Identifiers
IUPAC name
5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid
IUPAC Traditional name
aurintricarboxylic acid
Synonyms
ATA金精三羧酸Aurintricarboxylic acid
Properties
Safety Information
MSDS Link
GHS Signal Word
Warning
GHS Precautionary statements
P261-P305+P351+P338
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
German water hazard class
3
GHS Hazard statements
H315-H319-H335
RTECS
GU4790000
European Hazard Symbols
Irritant (Xi)Risk Statements
36/37/38
Safety Statements
26
Physical Property
Absorption Wavelength
λmax 552 nm
Melting Point
300 °C(lit.)
Product Information
Empirical Formula (Hill Notation)
C22H14O9
Compostion
Dye content, 85%
Molecule Details
Biochem/physiol Actions
Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease that is activated during apoptosis.
Other Notes
May contain a substantial amount of polymeric material
Application
Used extensively as a powerful inhibitor of cellular processes which are dependent on the formation of protein-nucleic acid complexes.1,2
Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease that is activated during apoptosis.
Other Notes
May contain a substantial amount of polymeric material
Application
Used extensively as a powerful inhibitor of cellular processes which are dependent on the formation of protein-nucleic acid complexes.1,2
Molecular Spectra
No Data Available
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References
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