Molecule

02154800 

Free Acid

05207718 

MP Biomedicals Rare Chemical collection

Aurintricarboxylic_acid 

A1895 

Biochem/physiol Actions
易于在水溶液中聚合，形成可抑制蛋白质-核酸相互作用的稳定自由基。它是核糖核酸酶和拓扑异构酶 II 的强效抑制剂，作用机理是阻止核酸与酶的结合。其可促进酪氨酸磷酸化过程，包括 NB2 淋巴瘤细胞中的 Jak2/STAT5 通路，神经母细胞瘤细胞中的 ErbB4，以及 PC12 细胞中的 MAP 激酶、Shc 蛋白、磷脂酰肌醇 3-激酶和磷脂酶 Cγ。抑制细胞凋亡。它可阻止对 Ca2+ 不通透的 GluR2 受体的下调并抑制钙蛋白酶，这是一种在细胞凋亡过程中被活化的 Ca2+ -激活蛋白酶。

123269 

Biochem/physiol Actions
Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease that is activated during apoptosis.
Other Notes
May contain a substantial amount of polymeric material
Application
Used extensively as a powerful inhibitor of cellular processes which are dependent on the formation of protein-nucleic acid complexes.1,2

CHEBI:87397 

A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.