Substance
ID:183772
Names and Identifiers
Synonyms
CAPECaffeic acid phenethyl ester
IUPAC name
2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
IUPAC Traditional name
caffeic acid phenethyl ester
Properties
Product Information
Purity
≥97% (HPLC)
Physical Property
Solubility
ethyl acetate: soluble50 mg/mL
DMSO: soluble
ethanol: soluble
Apperance
off-white powder
Pharmacology Properties
Gene Information
human ... NFKB2(4791)
Safety Information
GHS Signal Word
Warning
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Hazard statements
H315-H319-H335
Risk Statements
36/37/38
European Hazard Symbols
Irritant (Xi)Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements
P261-P305+P351+P338
Storage Condition
protect from light
German water hazard class
3
Storage Temperature
-20°C
RTECS
UD3334375
Safety Statements
26-36
Molecule Details
Biochem/physiol Actions
Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor NF-κB.
Application
Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product.1 Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB.2 CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.3,4 Caffeic acid phenethyl ester inhibits HIV-1 integrase,5,6 and also inhibits proliferation of transformed cells.7,8 It induces apoptosis in transformed fibroblasts,9 and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.7
Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor NF-κB.
Application
Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product.1 Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB.2 CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.3,4 Caffeic acid phenethyl ester inhibits HIV-1 integrase,5,6 and also inhibits proliferation of transformed cells.7,8 It induces apoptosis in transformed fibroblasts,9 and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.7
Molecular Spectra
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References
No Data Available
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