Molecule

Caffeic_acid_phenethyl_ester 

02195860 

Purity: >97%
Active component of propolis from honeybee hives. Possesses anti-viral, anti-inflammatory and immunomodulary properties. Inhibits growth of several types of transformed cells and induces apoptosis in cloned rat embryo fibroblast (CREF) cells.

02193775 

A cytotoxic agent to cancer cell lines. Acts as an inhibitor of protein tyrosine kinase and ornithine decarboxylase.

C8221 

Biochem/physiol Actions
Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor NF-κB.
Application
Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product.1 Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB.2 CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.3,4 Caffeic acid phenethyl ester inhibits HIV-1 integrase,5,6 and also inhibits proliferation of transformed cells.7,8 It induces apoptosis in transformed fibroblasts,9 and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.7

C080050 

Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase p