Substance
ID:182855
Names and Identifiers
Synonyms
Cefotaxim sodium salt 钠盐Cefotaxime sodium saltCefotaxime sodium salt 钠盐
IUPAC Traditional name
sodium cefotaxime(1-)
IUPAC name
sodium (6R,7R)-3-[(acetyloxy)methyl]-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Registration numbers
Beilstein Number
CAS Number
EC Number
MDL Number
PubChem SID
Properties
Safety Information
GHS Precautionary statements
P261-P280-P342+P311
Risk Statements
42/43
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Signal Word
Danger
German water hazard class
2
GHS Hazard statements
H317-H334
Storage Temperature
2-8°C
European Hazard Symbols
Harmful (Xn)RTECS
XI0250000
Safety Statements
22-36/37
Product Information
Potency
916-964 μg per mg
Suitability
suitable for 1694 per US EPA
Molecule Details
Biochem/physiol Actions
Used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP2 on bacterial cell wall mucopeptide synthesis.
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Other Notes
Broad spectrum third generation cephalosporin antibiotic.
Application
Cefotaxim is a broad spectrum third generation cephalosporin antibiotic that is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP2 on bacterial cell wall mucopeptide synthesis. It has been used to find new residues involved in cefotaxime hydrolysis in CTX-M β-lactamases1, to study antibiotic-susceptible and -resistant Streptococcus pneumoniae infections 2, and to study pneumococcal pneumonia and the pharmokinetics of various treatments3.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
Used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP2 on bacterial cell wall mucopeptide synthesis.
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Other Notes
Broad spectrum third generation cephalosporin antibiotic.
Application
Cefotaxim is a broad spectrum third generation cephalosporin antibiotic that is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP2 on bacterial cell wall mucopeptide synthesis. It has been used to find new residues involved in cefotaxime hydrolysis in CTX-M β-lactamases1, to study antibiotic-susceptible and -resistant Streptococcus pneumoniae infections 2, and to study pneumococcal pneumonia and the pharmokinetics of various treatments3.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
Molecular Spectra
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References
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