Molecule

C242950 

Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group.

C7039 

Other Notes
Broad spectrum third generation cephalosporin antibiotic.
Biochem/physiol Actions
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Cefotaxime, a cephalosporin antibiotic, is active against both gram-negative and gram-positive bacteria. In addition, cefotaxime blocks the division of cyanobacteria and lower plant organelles/plastids such as the photosynthetic organelles of Glaucophytes and chloroplasts of bryophytes.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

C7912 

Biochem/physiol Actions
Used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP2 on bacterial cell wall mucopeptide synthesis.
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Other Notes
Broad spectrum third generation cephalosporin antibiotic.
Application
Cefotaxim is a broad spectrum third generation cephalosporin antibiotic that is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP2 on bacterial cell wall mucopeptide synthesis. It has been used to find new residues involved in cefotaxime hydrolysis in CTX-M β-lactamases1, to study antibiotic-susceptible and -resistant Streptococcus pneumoniae infections 2, and to study pneumococcal pneumonia and the pharmokinetics of various treatments3.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

CHEBI:3498 

A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.