Substance
ID:180614
Names and Identifiers
Synonyms
tretinoinATRAVitamin A acidRetinoic acidall-trans-Retinoic acid
IUPAC Traditional name
tretinoin
IUPAC name
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
Registration numbers
CAS Number
MDL Number
EC Number
Beilstein Number
PubChem SID
Properties
Safety Information
Risk Statements
22
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
RTECS
VH6475000
Storage Temperature
-20°C
German water hazard class
2
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Warning
European Hazard Symbols
Harmful (Xn)GHS Hazard statements
H302
Safety Statements
61
Product Information
Purity
≥98% (HPLC)
Pharmacology Properties
Gene Information
human ... RARA(5914), RARB(5915), RARG(5916), RXRA(6256), RXRB(6257), RXRG(6258)mouse ... Rara(19401), Rarb(218772), Rarg(19411), Rxrb(20182)
Physical Property
Apperance
yellow powder
Melting Point
180-181 °C(lit.)
Molecule Details
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
包装
1, 5 g in ampule
50, 100, 500 mg in ampule
Sealed ampule
Biochem/physiol Actions
all-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R2625.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Live Chat and Frequently Asked Questions are available for this Product.
包装
1, 5 g in ampule
50, 100, 500 mg in ampule
Sealed ampule
Biochem/physiol Actions
all-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R2625.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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