Substance
ID:1347
Names and Identifiers
Synonyms
1-(4-Chlorophenyl)-2-methyl-2-propanamineChlorphentermine1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochlorideChlorphenteramineChlorphentermine hydrochlorideChlorphenterminum hydrochlorideP-chlorphentermine hydrochloridealpha,alpha-dimethyl-p-chlorophenethylamine4-Chloro-alpha,alpha-dimethylphenethylamineChlorophentermineChlorpentermineBeta-(p-chlorophenyl)-alpha,alpha-dimethylethylamineChlorophentermine hydrochlorideChlorphenterminum [inn-latin]Clorfentermina [inn-spanish]P-chloro-alpha,alpha-dimethylphenethylamine1-(p-Chlorophenyl)-2-methyl-2-aminopropane4-Chloro-alpha,alpha-dimethylbenzeneethanamine
Brand Name
ApsedonDezopimonClominaEffoxPre-sateLucofenLucofeneNilganaTeramineDesopimon
IUPAC Traditional name
chlorphentermine
IUPAC name
1-(4-chlorophenyl)-2-methylpropan-2-amine
Properties
Physical Property
Hydrophobicity(logP)
2.60 [HANSCH,C ET AL. (1995)]
Molecule Details
Drug Groups
illicit; experimental; withdrawn
Description
A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
Indication
Used as an appetite suppressant.
Pharmacology
Chlorphentermine is a relatively weak stimulant with little abuse potential. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.
Absorption
Well absorbed following oral administration.
Half Life
40 hours
References
•
GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73. Pubmed