CAS 461-78-9|CAS 151-06-4|Chlorophentermine hydrochloride|Chlorphenteramine|Chlorphentermine|Chlorpentermine|Chlorphenterminum [inn-latin]|Clomina|4-Chloro-alpha,alpha-dimethylphenethylamine|Lucofen...

General Information

Structure

Molecular Formula

C₁₀H₁₄ClN

Molecular Mass

183.67786

Exact Mass

183.08147713

Charge

InChI

InChI=1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3

InChIKey

ZCKAMNXUHHNZLN-UHFFFAOYSA-N

Canonic Smiles

CC(Cc1ccc(cc1)Cl)(N)C

Isomeric Smiles

Clc1ccc(CC(N)(C)C)cc1

Calculated Properties

JChem

H Acceptors

H Donor

LogD (pH = 5.5)

-0.3357499

LogD (pH = 7.4)

0.06515853

Log P

2.6888719

Molar Refractivity

53.1482

Polarizability

21.005404

Polar Surface Area

26.02

Rotatable Bonds

Lipinski's Rule of Five

true

ALOGPS 2.1

Log P

2.81

LOG S

-3.24

Solubility (Water)

1.05e-01 g/l

Data Source

Academic Data

Commercial Catalog

Data Source

Names and Identifiers

IUPAC name

1-(4-chlorophenyl)-2-methylpropan-2-amine

Synonyms

ChlorpentermineChlorphenterminum [inn-latin]ChlorphenteramineChlorphentermine4-Chloro-alpha,alpha-dimethylphenethylamineChlorophentermine hydrochlorideChlorphenterminum hydrochloride1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochlorideBeta-(p-chlorophenyl)-alpha,alpha-dimethylethylamine1-(p-Chlorophenyl)-2-methyl-2-aminopropaneP-chlorphentermine hydrochloridealpha,alpha-dimethyl-p-chlorophenethylamine4-Chloro-alpha,alpha-dimethylbenzeneethanamineClorfentermina [inn-spanish]P-chloro-alpha,alpha-dimethylphenethylamineChlorphentermine hydrochloride1-(4-Chlorophenyl)-2-methyl-2-propanamineChlorophentermine2-(4-CHLORO-PHENYL)-1,1-DIMETHYL-ETHYLAMINE

Brand Name

ClominaLucofenNilganaApsedonDesopimonPre-sateTeramineEffoxDezopimonLucofene

IUPAC Traditional name

chlorphentermine

Names and Identifiers

Registration numbers

PubChem CID

10007

PubChem SID

16096480046505599

CAS Number

461-78-9151-06-4

Registration numbers

Properties

Physical Property

Hydrophobicity(logP)

2.60 [HANSCH,C ET AL. (1995)]

Product Information

Purity

98%

Properties

Related Proteins

No Data Available

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Molecular Spectra

No Data Available

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Molecule Details

DrugBank

DB01556

Drug Groups

illicit; experimental; withdrawn

Description

A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)

Indication

Used as an appetite suppressant.

Pharmacology

Chlorphentermine is a relatively weak stimulant with little abuse potential. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.

Absorption

Well absorbed following oral administration.

Half Life

40 hours

References

• GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73. [Pubmed]

External Links

• [Wikipedia]

Molecule Details

References

PubChem Literature

From Data Sources