Drug Groups

approved

Description

An antineoplastic agent that acts by alkylation. [PubChem]

Indication

For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.

Pharmacology

Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.

Toxicity

Symptoms of overdose include hematologic toxicity, especially with chronic overdosage.

Affected Organisms

Absorption

Well absorbed from the GI tract.

External Links