An antineoplastic agent that acts by alkylation. [PubChem]
Indication
For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.
Pharmacology
Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.
Toxicity
Symptoms of overdose include hematologic toxicity, especially with chronic overdosage.
