• Igalsbe, M. L. et al.; Bioorgan. Med. Chem Lett 19, 4984 (2009)
• Widely used phase-transfer catalyst; see Appendix 2. Some illustrative applications are given below:
• Benzanilides have been N-alkylated in the presence of NaOH and K2CO3: Synth. Commun., 18, 2011 (1988).
• It was the most effective catalyst studied for the cyclization of ?-amino acids to ?-lactams by methanesulfonyl chloride and KHCO3: Chem. Lett., 443 (1981).
• For phase-transfer catalyzed conversion of nitriles to amides by alkaline H2O2, see: Synthesis, 243 (1980).
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For use in the permanganate oxidation of benzylic positions, see Potassium permanganate, A12170.• The oxidation of primary alcohols to aldehydes by potassium chromate under phase-transfer conditions is better for higher homologues, where solubility in the aqueous phase is limited: Synthesis, 134 (1979). For phase-transfer catalyzed dichromate oxidation of secondary alcohols to ketones, see: Tetrahedron Lett., 1601 (1978).
• In the dehydrohalogenation of aryl 2-haloethyl ethers to give vinyl ethers, this catalyst was found much more effective than the corresponding halides or benzyltriethylammonium salts: Synthesis, 688 (1979).
Harmful (Xn)
