CAS 4205-91-8|Clonidine hydrochloride|Catapres|clonidine hydrochloride|N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride|[2-(2,6-二氯苯基)亚氨基]咪唑烷盐酸盐|Clonidine hydrochlor...

General Information

Structure

Molecular Formula

C₉H₁₀Cl₃N₃

Molecular Mass

266.5548

Exact Mass

264.99403038

Charge

InChI

InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H

InChIKey

ZNIFSRGNXRYGHF-UHFFFAOYSA-N

Canonic Smiles

Clc1cccc(c1NC1=NCCN1)Cl.Cl

Isomeric Smiles

c1ccc(c(c1Cl)NC1=NCCN1)Cl.Cl

Calculated Properties

JChem

H Acceptors

H Donor

LogD (pH = 5.5)

0.26298487

LogD (pH = 7.4)

1.6616611

Log P

2.4850886

Molar Refractivity

59.0888

Polarizability

21.926537

Polar Surface Area

36.42

Rotatable Bonds

Lipinski's Rule of Five

true

Data Source

Names and Identifiers

IUPAC name

N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

Synonyms

Clonidine hydrochlorideCatapres[2-(2,6-二氯苯基)亚氨基]咪唑烷盐酸盐Clonidine hydrochloride可乐定盐酸盐N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride2-(2,6-dichloroanilino)-2-imidazoline hydrochlorideN-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine HydrochlorideHaemitonNeuclonKatapresanST 155IsoglauconHemitonNormopresanCapresin2-(2,6-Dichloroanilino)-2-imidazoline hydrochlorideAtensina

IUPAC Traditional name

clonidine hydrochloride

Names and Identifiers

Registration numbers

EC Number

CAS Number

Beilstein Number

MDL Number

PubChem SID

PubChem CID

Registration numbers

Properties

Pharmacology Properties

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Properties

Related Proteins

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Molecular Spectra

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Molecule Details

Selleck Chemicals

S2458

Research Area: Cardiovascular Disease
Biological Activity:
Clonidine hydrochloride(Catapres) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg. [1] It treats high blood pressure by stimulating α2 receptors in the brain, which decreases cardiac output and peripheral vascular resistance, lowering blood pressure. It has specificity towards the presynaptic α2 receptors in the vasomotor center in the brainstem. This binding decreases presynaptic calcium levels, and inhibits the release of norepinephrine (NE). The net effect is a decrease in sympathetic tone. [2]

MP Biomedicals

02190175

Hydrochloride
(2-(2,6-Dichloroaniline)-2-imidazoline)
Antihypertensive, α₂ -adrenoceptor agonist and imidazoline receptor ligand.

Sigma Aldrich

C7897

Biochem/physiol Actions
α2-adrenoceptor agonist; I1 imidazoline binding site ligand.

27545

Other Notes
Interacts with α-adrenergic receptors1

TRC

C587130

Labelled Clonidine. α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.

Molecule Details