Isothipendyl is an antihistamine and anticholinergic used as an antipruritic.
Indication
For the topical treatment of itching associated with allergic reactions.
Pharmacology
Isothipendyl, an azaphenothiazine derivative, competitively binds to histamine (H1) receptors, resulting in inhibition of the pharmacological effects of histamines. It also has some sedative, anticholinergic and antiserotoninergic effects.
Affected Organisms
Humans and other mammals
References
•
Moreau A, Dompmartin A, Dubreuil A, Leroy D: Phototoxic and photoprotective effects of topical isothipendyl. Photodermatol Photoimmunol Photomed. 1995 Apr;11(2):50-4.
[Pubmed]
• Moreau A, Dompmartin A, Dubreuil A, Leroy D: Phototoxic and photoprotective effects of topical isothipendyl. Photodermatol Photoimmunol Photomed. 1995 Apr;11(2):50-4. Pubmed
• Turcant, A., et al.: Clin. Chem., 37, 1210 (1985)
• Milsmann, E., et al.: Dermatologica, 170, 230 (1985)
