Reversible inhibitor of serine proteases, including chymotrypsin, trypsin, clotting factors XIa and XIIa. Also inhibits some endopeptidase such as protease (Staph. V-8). Does not inhibit papain.
Application Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.1 Other Notes Effective concentration 5-100 μM. Quantity Half-life = 20 min at pH 7.5. Substrates Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.
Other Notes Effective concentration 5-100 μM. Inhibitor of serine proteases1; Inhibition of porcine pancreatic elastase2 Quantity Half-life = 20 min at pH 7.5. Substrates Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases. Biochem/physiol Actions Inhibitor of serine proteases1 and porcine pancreatic elastase2. Treatment of proteasomes leads to rapid inactivation of chymotrypsin-like activity and slower inactivation of other proteases.3
Toxic (T)