CAS 18997-19-8|Pivaloylmethyl Chloride|CHLOROMETHYL PIVALATE|chloromethyl 2,2-dimethylpropanoate|chloromethyl 2,2-dimethylpropanoate|特戊酸氯甲酯|POM-Cl|Chloromethyl pivalate|新戊酸氯甲酯|Pivaloylox...

InChI=1S/C6H11ClO2/c1-6(2,3)5(8)9-4-7/h4H2,1-3H3

GGRHYQCXXYLUTL-UHFFFAOYSA-N

H Acceptors

H Donor

LogD (pH = 5.5)

2.3358417

LogD (pH = 7.4)

2.3358417

Log P

2.3358417

Molar Refractivity

35.7546

Polarizability

14.439058

Polar Surface Area

26.3

Rotatable Bonds

Lipinski's Rule of Five

true

Pivaloylmethyl ChlorideCHLOROMETHYL PIVALATE特戊酸氯甲酯POM-ClChloromethyl pivalate新戊酸氯甲酯Pivaloyloxymethyl chloride新戊酸氯甲酯Chloromethyl trimethylacetate

IUPAC Traditional name

chloromethyl 2,2-dimethylpropanoate

Click here to submit data

02150625

Purity: ~97%
1 ml=approx. 1.04 g
N-Protecting reagent for synthesis of purine derivatives.

141186

Packaging
25, 100 g in glass bottle

80915

Other Notes
Protecting group reagent for amines, used e.g. in adenine and xanthine derivatives1,2

• Reagent for the N-protection of amines, e.g. adenine in the presence of K₂CO₃ in DMF, as pivaloyloxymethyl (Pom) derivatives, which have been found useful in the synthesis of sensitive nucleosides. The Pom group is cleaved in mild base, e.g. methanolic ammonia: J. Am. Chem. Soc., 89, 5439 (1967).