Drug Groups

approved

Description

A fluorinated cytosine analog that is used as an antifungal agent. [PubChem]

Indication

For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).

Pharmacology

Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.

Toxicity

Oral, rat: LD₅₀ = >15 gm/kg.

Affected Organisms

Biotransformation

Flucytosine is deaminated, possibly by gut bacteria or by the fungal targets, to 5-fluorouracil, the active metabolite.

Absorption

Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.

Half Life

2.4 to 4.8 hours.

Protein Binding

28-31%

Elimination

Flucytosine is excreted via the kidneys by means of glomerular filtration without significant tubular reabsorption.
A small portion of the dose is excreted in the feces.

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