Deslanoside

名称和标识

商标名

Deacetyllanatoside CCedilanid-d

IUPAC标准名

4-[(1S,2S,5S,7R,10R,11S,14R,15S,16R)-11,16-dihydroxy-5-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-6-methyloxan-2-yl]oxy}-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]-2,5-dihydrofuran-2-one

别名

Deslanoside

IUPAC传统名

deslanoside

数据登录号

CAS号

17598-65-1

化合物性质

理化性质

疏水性(logP)

0.2

描述信息

Drug Groups

approved

Description

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata. [PubChem]

Indication

For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.

Pharmacology

Deslanoside is a cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.

Toxicity

Symptoms of overdose include ventricular tachycardia, ventricular fibrillation, progressive bradyarrhythmias, or heart block.

Affected Organisms

Humans and other mammals

Absorption

Little absorption from the gastrointestinal tract (40%).

Half Life

36 hours

Protein Binding

20%

External Links

• [Wikipedia]