Drug Groups

approved

Description

A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. [PubChem]

Indication

For the treatment of urinary tract infection

Pharmacology

Norfloxacin is a quinolone/fluoroquinolone antibiotic. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.

Affected Organisms

Biotransformation

Via liver and kidney

Absorption

Rapid

Half Life

3-4 hours

Protein Binding

10 and 15% (Serum protein binding)

Elimination

Norfloxacin is eliminated through metabolism, biliary excretion, and renal excretion.
Renal excretion occurs by both glomerular filtration and tubular secretion as evidenced by the high rate of renal clearance (approximately 275 mL/min).

References

External Links