物质信息

ID:932

名称和标识
商标名
EchodidePhospholine Iodide
IUPAC标准名
diethyl {[2-(trimethylazaniumyl)ethyl]sulfanyl}phosphonate
别名
EchothiophatePhospholinePhospholine IodideEchothiophate Iodide
IUPAC传统名
echothiophate
数据登录号
CAS号
PubChem SID
PubChem CID
化合物性质
理化性质
溶解度
Soluble
疏水性(logP)
-2.25
描述信息
Drug Groups
approved
Description
A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.
Indication
For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
Pharmacology
Echothiophate Iodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echothiophate iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.
Toxicity
Side effects include blurred vision or change in near or distant vision and eye pain.
Affected Organisms
Humans and other mammals
References
• Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. [Pubmed]
• Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. [Pubmed]
External Links
分子图谱
暂无数据
点击上传数据
参考文献
• Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. Pubmed
• Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. Pubmed