物质信息
ID:837
名称和标识
商标名
LemodMedrateMetilbetasoneMedroneMesoprenMetrisoneModerinNoretonaPromacortineFirmacortMedrol DosepakMedesoneMedrol Adt PakMetastabMetrocortSuprametilWyacortSolometUrbasoneBesoniaEsametoneDopomedrolMedixonMedlone 21NirypanReactenolSieropresolMetysolonPredni N TablinenSummicortUrbasonArtisone-Wyeth
别名
Metilprednisolone [Dcit]MethyleneprednisoloneMethylprednisolonMethylprednisolonum [INN-Latin]Metilprednisolona [INN-Spanish]6alpha-MethylprednisoloneMethylprednisolone
IUPAC传统名
methylprednisolone
IUPAC标准名
(1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
化合物性质
理化性质
疏水性(logP)
1.5
溶解度
120 mg/L
描述信息
Drug Groups
approved
Description
A prednisolone derivative with similar anti-inflammatory action. [PubChem]
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Toxicity
LD50=2000 mg/kg (orally in rat)
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic
Absorption
Oral bioavailability 80-99%
Half Life
1-3 hours
Protein Binding
78%
References
•
Sloka JS, Stefanelli M: The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler. 2005 Aug;11(4):425-32.
[Pubmed]
External Links
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参考文献
• Sloka JS, Stefanelli M: The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler. 2005 Aug;11(4):425-32. Pubmed