物质信息
ID:77
名称和标识
别名
Indecainidum [Latin]9-(3-(Isopropylamino)propyl)-9-fluorenylcarboxamid9-(3-(Isopropylamino)propyl))fluorene-9-carboxamideIndecainideRicainidRicainideIndecainida [Spanish]
IUPAC标准名
9-{3-[(propan-2-yl)amino]propyl}-9H-fluorene-9-carboxamide
IUPAC传统名
indecainide
商标名
Decabid
化合物性质
理化性质
疏水性(logP)
3.8
溶解度
1.88 mg/L
描述信息
Drug Groups
approved
Description
Indecainide is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.
Indication
For the treatment of life-threatening dysrhythmias and sustained ventricular tachycardia.
Pharmacology
Indecainide is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.
Toxicity
When given orally to either young adult rats or mice, the LD50 was 100 mg/kg. Symptoms of overdose include nausea and vomiting, convulsions, hypotension, bradycardia, syncope, extreme widening of the QRS complex, widening of the QT interval, widening of the PR interval, ventricular tachycardia, AV nodal block, asystole, bundle branch block, cardiac failure, and cardiac arrest.
Affected Organisms
Humans and other mammals
Absorption
Nearly complete following oral administration.
References
•
Giardina EV, Saroff AL, Schneider M: Effect of indecainide in patients with left ventricular dysfunction. Clin Pharmacol Ther. 1990 Nov;48(5):582-9.
[Pubmed]
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参考文献
• Giardina EV, Saroff AL, Schneider M: Effect of indecainide in patients with left ventricular dysfunction. Clin Pharmacol Ther. 1990 Nov;48(5):582-9. Pubmed