Research Area: cancer
Biological Activity:
10-DAB (10-Deacetylbaccatin) is an antineoplastic agent and an anti-cancer intermediate. 10-DAB (10-Deacetylbaccatin) has gained great attention because of its partly excellent anti-cancer properties. 10-DAB (10-Deacetylbaccatin) can be gained from the leaves of yew trees and 10-DAB (10-Deacetylbaccatin) is used as starting materials for numerous partial syntheses. The esterification of 10-DAB (10-Deacetylbaccatin) with longchain fatty acids can also generate an important enhancement of their kinetics and consequently their pharmacological action pattern. 10-DAB (10-Deacetylbaccatin) was first succinylated by use of dimethylaminopyridine and succinic anhydride in dried pyridine. [1][2]References on 10-DAB (10-Deacetylbaccatin)[1] Nat Prod Res. , 2006 Feb, 20(2):119-24[2] Biol Pharm Bull. , 2011, 34(4):562-6