Biological Activity:
(R)-Bicalutamide is an active competitive non-steroidal androgen receptor antagonist with an IC50 of 0.17 μM for MDA 453 cells. (R)-Bicalutamide possesses virtually all activities. (R)-Bicalutamide is the leading antiandrogen. (R)-Bicalutamide is used for the treatment of prostate cancer and breast cancer. (R)-Bicalutamide prevents the activation of the androgen receptor and subsequent upregulation of androgen responsive genes by androgenic hormones. In addition, (R)-bicalutamide accelerates the degradation of the androgen receptor. [1][2][3]References on (R)-Bicalutamide[] PNAS, April 26, 2005, 102:6201–6206[] THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277:26321–26326[] J Pharmacol Exp Ther, 2005 February, 312(2): 546–553