物质信息
ID:73979
名称和标识
别名
Neohesperidin
IUPAC标准名
(2S)-7-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-5-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
IUPAC传统名
(2S)-7-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-5-methoxyphenyl)-2,3-dihydro-1-benzopyran-4-one
数据登录号
CAS号
化合物性质
安全信息
保存条件
-20°C
产品相关信息
成盐信息
Free Base
描述信息
Research Area: Metabolic Disease
Biological Activity:
Neohesperidin is an antioxidant agent with an IC50 of 22.31 µg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay.Neohesperidin (50 mg/kg) significantly inhibited 55.0% of HCl/ethanol-induced gastric lesions, and increased the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. In addition, neohesperidin inhibited the efflux of the P-glycoprotein substrate rhodamine 123 in a concentration-dependent manner. Neohesperidin also inhibits the growth of Caco-2, CEM/ADR5000 and CCRF-CEM leukaemia cells with IC50 of 0.17, 0.17 and 0.12 mM, respectively. Neohesperidin can be isolated from ethyl acetate fractions of C. jambhiri. [1][2]
Biological Activity:
Neohesperidin is an antioxidant agent with an IC50 of 22.31 µg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay.Neohesperidin (50 mg/kg) significantly inhibited 55.0% of HCl/ethanol-induced gastric lesions, and increased the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. In addition, neohesperidin inhibited the efflux of the P-glycoprotein substrate rhodamine 123 in a concentration-dependent manner. Neohesperidin also inhibits the growth of Caco-2, CEM/ADR5000 and CCRF-CEM leukaemia cells with IC50 of 0.17, 0.17 and 0.12 mM, respectively. Neohesperidin can be isolated from ethyl acetate fractions of C. jambhiri. [1][2]
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参考文献
• Lee JH et al. Phytother Res. 2009 Dec;23(12):1748-53.