Research Area: Neurological Disease
Biological Activity:
Gallamine triethiodide(Flaxedil) is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 µM. It is a non-depolarising muscle relaxant. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. It has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. [1][2]