物质信息
ID:73761
名称和标识
IUPAC标准名
(1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
IUPAC传统名
asiatic acid
别名
Asiatic acid
数据登录号
CAS号
化合物性质
产品相关信息
成盐信息
Free Base
安全信息
保存条件
-20°C
描述信息
Research Area: Cancer
Biological Activity:
Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. It is a neuroprotectant and inducer of apoptosis in HepG2 human hepatoma cells. It was likely to confine the breast cancer cells in the S-G2/M phase mainly through the p38 pathway, because both SB203580 and p38 small interfering RNA (siRNA) inhibition significantly attenuated the accumulation of inactive phospho-Cdc2 and phospho-Cdc25C proteins and the cell numbers of S-G2/M phase. [1]References on Asiatic acid[1] J Pharmacol Exp Ther., 2005 Apr, 313(1):333-44.
Biological Activity:
Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. It is a neuroprotectant and inducer of apoptosis in HepG2 human hepatoma cells. It was likely to confine the breast cancer cells in the S-G2/M phase mainly through the p38 pathway, because both SB203580 and p38 small interfering RNA (siRNA) inhibition significantly attenuated the accumulation of inactive phospho-Cdc2 and phospho-Cdc25C proteins and the cell numbers of S-G2/M phase. [1]References on Asiatic acid[1] J Pharmacol Exp Ther., 2005 Apr, 313(1):333-44.
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参考文献
• Hsu YL et al. J Pharmacol Exp Ther. 2005 Apr;313(1):333-44.