物质信息
ID:73733
名称和标识
IUPAC传统名
2-({4-aminopyrazolo[3,4-d]pyrimidin-1-yl}methyl)-5-methyl-3-(2-methylphenyl)quinazolin-4-one
IUPAC标准名
2-({4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl}methyl)-5-methyl-3-(2-methylphenyl)-3,4-dihydroquinazolin-4-one
别名
PIK-293
数据登录号
CAS号
化合物性质
药理学性质
作用靶点
PI3K
安全信息
保存条件
-20°C
产品相关信息
成盐信息
Free Base
描述信息
Research Area
Description
Cancer
Biological Activity
Description
PIK-293 is a PI3-K inhibitor for p110α, p110β, p110δ and p110γ with IC50 of 100 μM, 25 μM, 0.24 μM and 10 μM, respectively.
Targets
p110α
IC50
100 μM
In Vitro
PIK-293 is a pyrazolopyrimidine analog of IC87114. PIK-293 is synthesized by replacing the adenine of IC87114 with the isosteric pyrazolopyrimidine. [1]
In Vivo
Clinical Trials
Features
分子图谱
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参考文献
• Knight ZA et al. Cell, 2006, 125(4), 733-747.