物质信息
ID:737317
名称和标识
IUPAC传统名
9-bromo-9-phenylfluorene
IUPAC标准名
9-bromo-9-phenyl-9H-fluorene
别名
9-Bromo-9-phenylfluorene9-溴-9-苯基芴
化合物性质
安全信息
TSCA收录
否
GHS危险品标识
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
联合国危险货物包装类别(PG)
II
危险公开号
34
安全公开号
20-26-36/37/39-45
GHS危险声明
H314-H318
联合国危险货物编号
UN3261
GHS警示性声明
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
联合国危险货物等级
8
欧盟危险性物质标志
腐蚀性 (C)产品相关信息
纯度
96%
理化性质
熔点
94-99°C
描述信息
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分子图谱
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参考文献
• The Pf ester has also been developed for protection of the -carboxy group of glutamic acid in peptide synthesis, with better stability than trityl, but readily cleaved by TFA in DCM: Synlett, 1136 (1999).
• Reagent for protection of amines as their N-9-phenylfluorenyl (Pf) derivatives, which are ca 6000x more stable than trityl (Trt) groups (see Chlorotriphenylmethane, A11799) to acid hydrolysis: J. Chem. Soc., 1895 (1964), and have been found useful in asymmetric syntheses. The group has been introduced using K3PO4 or Et3N as base and Pb(NO3)2 as a bromide scavenger: J. Org. Chem., 50, 1239 (1985); 51, 3882 (1986). An alternative lead-free method uses K3PO4 and nitromethane: J. Org. Chem., 58, 2369 (1993). The Pf group can be cleaved with TFA in acetonitrile. For examples and discussion, see: Org. Synth. Coll., 9, 344 (1998). Hydrogenolysis: J. Org. Chem., 60, 4602 (1995); 61, 9437 (1996), or Li/ammonia reduction: J. Org. Chem., 55, 3511 (1990) have also been reported. N-Pf- and N-Trt- derivatives of amino acids have also been converted to Leuchs' anhydrides by treatment with phosgene or triphosgene, and the products coupled with amino acid esters to give dipeptides in good yields without racemization: J. Org. Chem., 64, 2532 (1999).