物质信息
ID:736
名称和标识
商标名
AdermykonMaolateDemykonGecophenGechophenMycil
别名
Chlorphenesine [INN-French]Clorfenesina [INN-Spanish]Chlorphenesinalpha-Glyceryl etherChlorphenesinum [INN-Latin]Chlorophenesinp-Chlorophenylp-Chlorophenyl glyceryl ether
IUPAC标准名
3-(4-chlorophenoxy)propane-1,2-diol
IUPAC传统名
C9H11ClO3
化合物性质
理化性质
溶解度
1E+004 mg/L
疏水性(logP)
1.2
描述信息
Drug Groups
approved
Description
A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)
Indication
Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release.
Pharmacology
Chlorphenesin is a muscle relaxant. It blocks nerve impulses (or pain sensations) that are sent to the brain.
Toxicity
Symptoms of a chlorphenesin overdose include drowsiness and nausea.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite.
Absorption
Rapid and complete.
Half Life
2.3-5 hours
References
•
Malley A, Baecher L: Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin. J Immunol. 1971 Aug;107(2):586-8.
[Pubmed]
•
Kurachi M, Aihara H: Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Jpn J Pharmacol. 1984 Sep;36(1):7-13.
[Pubmed]
•
Dalessio DJ: Medical treatment of the major neuralgias. Semin Neurol. 1988 Dec;8(4):286-90.
[Pubmed]
External Links
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参考文献
• Malley A, Baecher L: Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin. J Immunol. 1971 Aug;107(2):586-8. Pubmed
• Kurachi M, Aihara H: Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Jpn J Pharmacol. 1984 Sep;36(1):7-13. Pubmed
• Dalessio DJ: Medical treatment of the major neuralgias. Semin Neurol. 1988 Dec;8(4):286-90. Pubmed