物质信息
ID:735619
名称和标识
IUPAC标准名
2,2,2-trichloroethan-1-ol
IUPAC传统名
trichloroethanol
别名
2,2,2-三氯乙醇2,2,2-Trichloroethanol
化合物性质
理化性质
沸点
151-153°C
密度
1.560
闪点
>110°C(230°F)
熔点
17-18°C
折射率
1.4895
产品相关信息
纯度
99%
安全信息
GHS危险声明
H318-H315-H302-H336
危险公开号
22-38-41-67
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
GHS警示性声明
P280-P305+P351+P338-P308+P313-P330-P501A
TSCA收录
是
RTECS编号
KM3850000
保存注意事项
Hygroscopic
安全公开号
26-36/37/39
欧盟危险性物质标志
有害性 (X)描述信息
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分子图谱
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参考文献
• Carboxyl groups can be protected as their trichloroethyl esters e.g. by tosic acid-catalyzed esterification: Synthesis, 24 (1979), or DCC-DMAP: J. Am. Chem. Soc., 111, 669 (1989). For esterification of amino acids, using the active ester with 2-Hydroxypyridine, A14522, see: Synthesis, 24 (1979). Cleavage occurs with Zn in AcOH or an aqueous THF buffer under mild conditions: J. Am. Chem. Soc., 88, 852 (1966); Synthesis, 457 (1976); or with NaBH4 in DMF, catalyzed by Se: Synthesis, 693 (1989). See also Appendix 6.
• Similarly, carbonyl compounds can be protected as their trichloroethyl acetals, stable to base, but readily cleaved under neutral aprotic conditions by Zn in ethyl acetate or THF: J. Org. Chem., 38, 554 (1973).
• Reaction with POCl3 to give the phosphorodichloridate, followed by reaction with 3-Hydroxypropionitrile, L12570, gives 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a valuable reagent, usually used without purification, for the phosphorylation of nucleosides: Synthesis, 831 (1980).