Research Area: Neurological Disease
Biological Activity:
Zolmitriptan(Zomig) is a selective serotonin receptor agonist. It is a triptan, used in the acute treatment of migraine attacks with or without aura and cluster headaches. Cytochrome 1A2 is likely to be the isoenzyme responsible for the metabolism of zolmitriptan. The increased exposure to zolmitriptan and 183C91 by cimetidine indicated that a reduction in the total daily recommended dose of zolmitriptan may be necessary when treating migraine patients who are taking nonspecific cytochrome P450 inhibitors or specific cytochrome 1A2 inhibitors. [1][2]