Research Area: Inflammation
Biological Activity:
Etodolac (Lodine) is a COX inhibitor with an IC50 of 53.5 nM. Etodolac (Lodine) belongs to a class of compounds called nonsteroidal anti-inflammatory agents (NSAIDs). Etodolac (Lodine) works by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac (Lodine) blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. [1][2]