物质信息
ID:717835
名称和标识
IUPAC传统名
phenacyl bromide
IUPAC标准名
2-bromo-1-phenylethan-1-one
别名
2-溴苯乙酮2-BromoacetophenonePhenacyl bromide
化合物性质
理化性质
闪点
>110°C(230°F)
熔点
48-51°C
沸点
140°C/11mm
密度
1.650
安全信息
TSCA收录
是
联合国危险货物编号
UN2645
危险公开号
23-34
欧盟危险性物质标志
有毒 (T)联合国危险货物等级
6.1
GHS危险声明
H331-H314-H318
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
安全公开号
26-36/37/39-45
联合国危险货物包装类别(PG)
II
GHS警示性声明
P280-P305+P351+P338-P309-P310
产品相关信息
纯度
98%
描述信息
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分子图谱
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参考文献
• For formation of the Sn enolate using SnCl2, see: Synth. Commun., 23, 271 (1993). 1,4-Diketones may be synthesized from ɑ-bromoketones and Sn enolates: J. Chem. Soc., Perkin 1, 3205 (1990).
• Has also been used to block the imidazole ring in histidine residues during peptide synthesis, and is stable to TFA, TfOH and HBr-AcOH: J. Chem. Soc., Chem. Commun., 472 (1978); J. Chem. Soc., Perkin 1, 2261 (1979).
• Reagent for carboxyl protection as phenacyl esters, stable to acid hydrolysis but readily cleaved by nucleophiles or by reduction. See Appendix 6. Protection can be effected in the presence of triethylamine: J. Chem. Soc. (C), 1191 (1966), or, better, KF in DMF: Tetrahedron Lett., 599 (1977). Phase-transfer conditions have also been reported: Synth. Commun., 26, 1747 (1996). Cleavage has been described using a variety of reagents, including Zn-AcOH: Tetrahedron Lett., 343 (1970), catalytic hydrogenolysis, treatment with PhS-, PhSeH, or NaHTe: Synth. Commun., 18, 116 (1988); TBAF: J. Org. Chem., 56, 5465 (1991); or photolysis: J. Org. Chem., 62, 6245 (1997).