物质信息
ID:717531
名称和标识
IUPAC传统名
hexamethyldisilizane
IUPAC标准名
bis(trimethylsilyl)amine
别名
HMDSHexamethyldisilazaneBis(trimethylsilyl)amine六甲基二硅杂氮烷
化合物性质
理化性质
密度
0.774
折射率
1.4080
闪点
8°C(46°F)
沸点
126°C
熔点
-78°C
安全信息
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
易燃气体类别1
易燃气溶胶，第1,2类
易燃液体，类别1,2,3
自反应物质和混合物，类型B，C，D，E，F
自燃液体类别1
自燃固体类别1
自我放热物质和混合物，类别1,2
与水接触的物质和混合物，放出易燃气体类别1,2,3
有机过氧化物，类别B，C，D，E，F
TSCA收录
是
RTECS编号
JM9230000
欧盟危险性物质标志
有害性 (X)
易燃性 (F)
腐蚀性 (C)GHS警示性声明
P210-P303+P361+P353-P305+P351+P338-P361-P405-P501A
联合国危险货物编号
UN2924
保存注意事项
Moisture Sensitive
联合国危险货物包装类别(PG)
II
GHS危险声明
H225-H311-H331-H302-H314-H318
危险公开号
11-20/21/22-34
联合国危险货物等级
3
安全公开号
16-26-33-36/37/39-45-60
产品相关信息
纯度
98+%
描述信息
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分子图谱
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参考文献
• In combination with DMSO, thiols are oxidized to disulfides under nearly neutral conditions: Synlett, 346 (2002).
• Convenient, mild silylating reagent which generates gaseous ammonia as the only by-product (see Appendix 4). Non-acidic substrates normally require a catalyst.
• Can also function as a protected form of ammonia, e.g. to convert acid chlorides to primary amides: Synthesis, 517 (1985), and substituted maleic anhydrides to maleimides: Tetrahedron Lett., 31, 5201 (1990).
• HMDS in the presence of TMS chloride permits the selective O-silylation of amino alcohols: Synthesis, 990 (1988). Alcohols and phenols can be silylated in the presence of amines and thiols with ZnCl2 as catalyst: Synth. Commun., 23, 1633 (1993).
• Silylation of alcohols, including carbohydrates, is catalyzed by TMS chloride: J. Org. Chem., 23, 50 (1958); J. Am. Chem. Soc., 85, 2497 (1963); Chem. Ind. (London), 794 (1984). Silylation of phenols occurs readily, see also: Liebigs Ann. Chem., 20 (1973).
• A range of catalysts for silylation with HMDS, including saccharin and sodium saccharin, has been recommended: J. Org. Chem., 47, 3966 (1982), for silylation of alcohols, phenols, thiols, carboxylic acids, amides, thioamides, hydroxamic acids, hydrazides, NH-groups of heterocycles, hydrazines, 1,3-diketones, etc. The use of TBAF (0.02 eq.) or iodine (0.01 eq.) also provide mild procedures for O-silylation: Tetrahedron Lett., 35, 8409 (1994); J. Org. Chem., 65, 7228 (2000).
• For conversion of carbonyl groups to silyl enol ethers, see Iodotrimethylsilane, A12902.
• The Na, Li and K derivatives are useful strong bases; see Sodium bis(trimethylsilyl)amide, L13352, Lithium bis(trimethylsilyl)amide, L15012, and Potassium bis(trimethylsilyl)amide, L15022.