物质信息
ID:717335
名称和标识
IUPAC标准名
2-bromo-1,3-thiazole
IUPAC传统名
thiazole, 2-bromo-
别名
2-Bromothiazole2-溴噻唑
化合物性质
产品相关信息
纯度
99%
理化性质
沸点
171°C
密度
1.836
闪点
63°C(145°F)
折射率
1.5930
安全信息
欧盟危险性物质标志
刺激性 (Xi)TSCA收录
是
危险公开号
36/37/38
安全公开号
26-37
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS警示性声明
P210-P305+P351+P338-P302+P352-P321-P405-P501A
GHS危险声明
H315-H319-H335-H227
描述信息
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分子图谱
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参考文献
• 2-Lithiothiazole can be obtained by direct lithiation of thiazole or, more conveniently, by exchange with 2-bromothiazole using n-BuLi: J. Org. Chem., 53, 1748 (1988). It behaves as a valuable formyl anion equivalent, and as such has been applied, mainly by Dondoni's group, in the syntheses of a variety of products; see, e.g.: Tetrahedron Lett., 34, 7319, 7323, 7327 (1993). See also 2-(Trimethylsilyl)thiazole, B21903. Reaction of 2-lithiothiazole with nitrones gives ɑ-aminoaldehydes: Tetrahedron Lett., 33, 4221 (1992); stereocontrolled addition to C-galacto-pyranosylnitrone has been used in syntheses of destomic acid, a component of the antibiotics destomycin and hygromycin, and of lincosamine, the sugar component of the anticancer antibiotic lincomycin: Synlett, 78 (1993). For applications of 2-lithiothiazole in the synthesis of the aza-sugar (+)-galactostsin, see: J. Org. Chem., 60, 4749 (1995). The Thiazole Aldehyde Synthesis has been reviewed by Dondoni: Synthesis, 1681 (1998).