物质信息
ID:716605
名称和标识
IUPAC标准名
2,2-dimethoxypropane
IUPAC传统名
2,2-dimethoxypropane
别名
2,2-Dimethoxypropane2,2-二甲氧基丙烷acetone dimethyl acetal
化合物性质
理化性质
密度
0.848
沸点
79-81°C
折射率
1.3780
熔点
-47°C
闪点
-11°C(12°F)
安全信息
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
易燃气体类别1
易燃气溶胶，第1,2类
易燃液体，类别1,2,3
自反应物质和混合物，类型B，C，D，E，F
自燃液体类别1
自燃固体类别1
自我放热物质和混合物，类别1,2
与水接触的物质和混合物，放出易燃气体类别1,2,3
有机过氧化物，类别B，C，D，E，F
联合国危险货物包装类别(PG)
II
GHS危险声明
H225-H319
安全公开号
9-16-23-26-33-60
欧盟危险性物质标志
易燃性 (F)
刺激性 (Xi)联合国危险货物编号
UN3271
危险公开号
11-36
TSCA收录
是
联合国危险货物等级
3
GHS警示性声明
P210-P305+P351+P338
产品相关信息
纯度
98%
描述信息
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分子图谱
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参考文献
• Methoxylating agent for preparation of acetals by acid-catalyzed exchange: J. Org. Chem., 25, 521 (1960). Also used as a water-scavenger in the preparation of acetals from higher-boiling alcohols and ketones: Org. Synth. Coll., 5, 292 (1973).
• Widely used for the isopropylidenation of diols; see, e.g.: Org. Synth. Coll., 9, 450, 717 (1998). Isopropylidenation of acid-sensitive carbohydrates in the presence of 2,3-Dichloro-5,6-dicyanobenzoquinone, A11879: Acta Chem. Scand., 47, 843 (1993); preparation of acyclic mixed acetals of carbohydrates: Acta Chem. Scand., 48, 80 (1994). For use in the cyclization of N-Boc serine methyl ester to the oxazolidine, see: Org. Synth. Coll., 9, 300 (1998).
• Methyl ester hydrochlorides of amino acids can be conveniently prepared with excess reagent in combination with conc. HCl. Water is removed in situ, thus displacing the equilibrium in favor of the ester: J. Org. Chem., 28, 3898 (1963). Methyl esters of non-aromatic acids can also be prepared with the reagent in MeOH with a catalytic amount of HCl or TMS chloride: Tetrahedron Lett., 38, 2685 (1997).