物质信息
ID:716594
名称和标识
IUPAC传统名
4-methoxybenzenesulfonyl chloride
IUPAC标准名
4-methoxybenzene-1-sulfonyl chloride
别名
4-甲氧基苯磺酰氯4-Methoxybenzenesulfonyl chloridep-Anisolesulfonyl chloride
化合物性质
理化性质
熔点
37-42°C
闪点
>110°C(230°F)
沸点
119-122°C/0.4mm
安全信息
GHS危险品标识
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
联合国危险货物等级
8
联合国危险货物包装类别(PG)
II
欧盟危险性物质标志
腐蚀性 (C)危险公开号
34
保存注意事项
Moisture Sensitive
GHS危险声明
H314-H318
GHS警示性声明
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
安全公开号
26-36/37/39-45
TSCA收录
否
联合国危险货物编号
UN3261
产品相关信息
纯度
98+%
描述信息
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分子图谱
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参考文献
• Amines and other N-functions can be protected as 4-methoxybenzenesufonyl (PMBS, Mps) derivatives: Chem. Pharm. Bull., 29, 2592 (1981), useful for the imidazole in histidines, stable to TFA and HBr/AcOH: Bull. Chem. Soc. Jpn., 47, 3146 (1974); J. Org. Chem., 45, 547 (1980); deprotection in TFA is promoted by dimethyl sulfide: J. Chem. Soc., Chem. Commun., 955 (1979). For deprotection of PMBS-indoles using Mg in methanol, see: J. Org. Chem., 62, 6519 (1997).
• Also used for protection of the guanidino function of arginine residues in peptide synthesis. The sulfonamide is cleaved by triflic acid under less drastic conditions than tosyl groups: Chem. Pharm. Bull., 24, 1568 (1976). Compare also 4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride, L11829. See Appendix 6.