物质信息
ID:716494
名称和标识
IUPAC标准名
chlorotrimethylsilane
IUPAC传统名
chlorotrimethylsilane
别名
Trimethylchlorosilane三甲基氯硅烷ChlorotrimethylsilaneTMS chloride
化合物性质
安全信息
欧盟危险性物质标志
有害性 (X)
腐蚀性 (C)
易燃性 (F)GHS危险品标识
易燃气体类别1
易燃气溶胶，第1,2类
易燃液体，类别1,2,3
自反应物质和混合物，类型B，C，D，E，F
自燃液体类别1
自燃固体类别1
自我放热物质和混合物，类别1,2
与水接触的物质和混合物，放出易燃气体类别1,2,3
有机过氧化物，类别B，C，D，E，F
急性毒性（口服，皮肤接触，吸入），类别1,2,3
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
TSCA收录
是
GHS警示性声明
P210-P303+P361+P353-P305+P351+P338-P361-P405-P501A
RTECS编号
VV2710000
保存注意事项
Moisture Sensitive
危险公开号
11-14-21-34
联合国危险货物等级
3
联合国危险货物包装类别(PG)
II
GHS危险声明
H225-H311-H314-H318
安全公开号
8-16-26-30-36/37/39-45-60
联合国危险货物编号
UN1298
理化性质
熔点
-58°C
密度
0.856
沸点
56-58°C
折射率
1.3887
闪点
-27°C(-16°F)
产品相关信息
纯度
98+%
描述信息
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分子图谱
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参考文献
• For facile O-silylation of tertiary alcohols in the presence of Mg metal, see: Synlett, 1025 (2000).
• For cleavage of ethers, see Sodium iodide, A15480.
• Conjugated enones give trimethylsilyloxydienes. For examples, see: Org. Synth. Coll., 6, 445 (1988); 7, 282 (1990). TMS chloride, LiBr and trimethylamine in THF is a convenient system for silylation of enones: Acta Chem. Scand., 43, 188 (1989). The same combination converts ɑ- and ?-diketones to their bis silyl enol ethers: Acta Chem. Scand., 43, 304 (1989). See also Trimethylsilyl trifluoromethanesulfonate, A12535.
• Carbonyl compounds can be converted to their silyl enol ethers, e.g. with triethylamine in DMF: Org. Synth. Coll., 6, 327 (1988); 7,424 (1990); 8, 460 (1993); or using catalysis with NaI: Org. Synth. Coll., 9, 573 (1998).
• For further details and reviews, see Appendix 4.
• The conversion of alcohols to alkyl chlorides requires catalysis, e.g. SeO2: J. Org. Chem., 53, 3634 (1988), or by DMSO: J. Org. Chem., 60, 2638 (1995). The same system is also effective in opening epoxides.
• Silylation at carbon atoms is usually carried out using organometallic reagents, e.g. vinylmagnesium bromide: Org. Synth. Coll., 6, 1033 (1988). In aromatic rings, silyl groups can be introduced by directed metallation, followed by silylation; see e.g.: J. Org. Chem., 49, 4657 (1989). The silyl substituents can readily be replaced by electrophiles, allowing "abnormal" patterns of substitution. See 1,3-Dimethoxybenzene, A13380.