物质信息
ID:715765
名称和标识
IUPAC标准名
3-ethoxy-3-oxopropanoic acid
IUPAC传统名
ethyl hydrogen malonate
别名
丙二酸氢乙酯Malonic acid monoethyl esterMonoethyl malonateEthyl hydrogen malonate
化合物性质
产品相关信息
纯度
96%
理化性质
折射率
1.4295
沸点
106°C/3mm
闪点
>110°C(230°F)
密度
1.119
安全信息
欧盟危险性物质标志
刺激性 (Xi)GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS危险声明
H315-H319-H335
危险公开号
36/37/38
安全公开号
26-37-60
GHS警示性声明
P261-P305+P351+P338-P302+P352-P321-P405-P501A
TSCA收录
否
描述信息
暂无数据
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分子图谱
暂无数据
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参考文献
• See also Ethyl potassium malonate, A10720.
• Half esters of malonic acid react with ɑ?-enals in pyridine/DMAP to give ɑ? δ-dienoic esters with good (E)-selectivity: Synthesis: 534 (1988).
• Carbodiimide coupling with polymer-bound ɑ-amino acids has been used in the solid-phase synthesis of substituted tetramic acids; J. Org. Chem., 63, 4808 (1998).
• The O,ɑ-dilithio-derivative, formed with n-BuLi in THF, can be acylated with acid chlorides to give, on acidic work-up (in situ decarboxylation), ?-ketoesters directly in high yield: J. Org. Chem., 44, 310 (1979); Org. Synth. Coll., 7, 213 (1990). Similarly, alkylation of the dilithio-derivative provides a direct route to esters of substituted acetic acids: J. Org. Chem., 40, 2556 (1975).
• Reaction with alkyl chloroformates results in decarboxylation of the mixed anhydride in situ, providing a route to mixed ethyl alkyl malonates in high yield under very mild conditions: Tetrahedron Lett., 26, 1573 (1985).