物质信息
ID:715533
名称和标识
IUPAC标准名
1,1,3,3-tetramethylguanidine
IUPAC传统名
1,1,3,3-tetramethylguanidine
别名
1,1,3,3-四甲基胍1,1,3,3-TetramethylguanidineTMG
化合物性质
安全信息
欧盟危险性物质标志
腐蚀性 (C)
有害性 (X)保存注意事项
Air Sensitive
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
易燃气体类别1
易燃气溶胶，第1,2类
易燃液体，类别1,2,3
自反应物质和混合物，类型B，C，D，E，F
自燃液体类别1
自燃固体类别1
自我放热物质和混合物，类别1,2
与水接触的物质和混合物，放出易燃气体类别1,2,3
有机过氧化物，类别B，C，D，E，F
危险公开号
22-34
安全公开号
26-36/37/39-45
联合国危险货物等级
8
GHS危险声明
H301-H314-H318-H226
TSCA收录
是
联合国危险货物包装类别(PG)
II
GHS警示性声明
P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501A
联合国危险货物编号
UN2920
理化性质
沸点
162°C
密度
0.918
熔点
<-30°C
折射率
1.4690
闪点
60°C(140°F)
产品相关信息
纯度
99%
描述信息
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分子图谱
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参考文献
• Inexpensive and efficient ligand for the palladium-catalyzed Heck reaction: Synlett, 1885 (2005).
• Other uses include: Acylation of amino acids by methyl trifluoroacetate: Synthesis, 399 (1976). Formation of Boc-amino acids with tert-butyl phenyl carbonate: Org. Synth. Coll., 6, 203 (1988). Cleavage of peptides from resins: Tetrahedron, 40, 4237 (1984). Selective cleavage of a primary benzyloxycarbonyl (Cbz, Z) group in the presence of either Boc or secondary Cbz: J. Chem. Soc., Perkin 1, 1905 (1988). See also 4-Chloromethylpyridine hydrochloride, A12859 and Appendix 6.
• Strong organic base useful for the formation of organic-soluble salts, and as a basic catalyst, e.g. in Michael addition reactions: J. Org. Chem., 27, 3175 (1962); Tetrahedron Lett., 569 (1973). Preferred catalyst in the Michael addition of aliphatic nitro compounds to unsaturated esters: Synthesis, 44 (1972); 953 (1989); Tetrahedron Lett., 30, 993 (1989).
• Useful base for formation of TBDMS ethers of alcohols with tert-Butyldimethylchlorosilane, A13064: J. Org. Chem., 49, 4657 (1984).
• For use in the Baylis-Hillman reaction, see: J. Chem. Soc., Perkin 1, 2831 (2001).