物质信息
ID:714971
名称和标识
IUPAC标准名
ethyl 2-cyanoacetate
IUPAC传统名
ethyl cyanoacetate
别名
Ethyl cyanoacetateCyanoacetic acid ethyl ester氰基乙酸乙酯
化合物性质
理化性质
闪点
109°C(228°F)
折射率
1.4180
密度
1.063
沸点
208-210°C
熔点
-23°C
安全信息
GHS警示性声明
P261-P305+P351+P338
欧盟危险性物质标志
刺激性 (Xi)TSCA收录
是
危险公开号
36
RTECS编号
AG4110000
安全公开号
23-26
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS危险声明
H319
产品相关信息
纯度
98+%
描述信息
暂无数据
点击上传数据
分子图谱
暂无数据
点击上传数据
参考文献
• Arylation by aryl iodides is promoted by copper(I) iodide: Synthesis, 67 (1983); J. Org. Chem., 58, 7606 (1993); or trans-Dichlorobis(triphenylphosphine)palladium(II), 10491: Synthesis, 506 (1985).
• For use in the synthesis of pyrrole derivatives, see p-Toluenesulfonylmethyl isocyanide, A14312.
• Stereoselective alkylation of the active methylene has been accomplished under particularly mild conditions with secondary alkyl mesylates in the presence of CsF in DMF; complete inversion occurs at the secondary alkyl carbon: J. Org. Chem., 60, 2627 (1995).
• For examples of Knoevenagel condensations of cyanoacetic esters with carbonyl compounds, see: Org. Synth. Coll., 3, 385, 399 (1955); 4, 93, 463 (1963); review: Org. React., 15, 204 (1967). Knoevenagel condensation with aromatic aldehydes has also been carried out under acidic conditions, for example, good yields have been obtained with ZnCl2: Tetrahedron Lett., 32, 5821 (1991).