物质信息
ID:713374
名称和标识
别名
Sanger's Reagent1-Fluoro-2,4-dinitrobenzene2,4-Dinitrofluorobenzene2,4-二硝基-1-氟苯
IUPAC传统名
dinitrofluorobenzene
IUPAC标准名
1-fluoro-2,4-dinitrobenzene
化合物性质
产品相关信息
纯度
99%
安全信息
RTECS编号
CZ7800000
GHS危险品标识
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
急性毒性（口服，皮肤接触，吸入），类别1,2,3
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
危险公开号
23/24/25-38-41-43-68
联合国危险货物编号
UN2811
欧盟危险性物质标志
有毒 (T)联合国危险货物等级
6.1
联合国危险货物包装类别(PG)
III
GHS警示性声明
P261-P301+P310-P305+P351+P338-P361-P405-P501A
安全公开号
24-26-36/37/39-45
GHS危险声明
H301-H311-H331-H315-H317-H318-H341
TSCA收录
是
理化性质
折射率
1.5690
密度
1.482
熔点
24-30°C
沸点
296°C
闪点
>110°C(230°F)
描述信息
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分子图谱
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参考文献
• Has been used as a means of protection for the thiol group. The resulting thioether can be cleaved quantitatively with 2-mercaptoethanol: Biochem. Biophys. Res. Commun., 29, 178 (1967).
• Used for labelling terminal amino acids in peptides: Biochem. J., 45, 563 (1949); Biochemistry, 20, 512 (1981).
• The activated fluoro-substituent is readily displaced by nucleophiles under mild conditions. The anomeric center of a carbohydrate has been protected as the 2,4-dinitrophenyl ether in the presence of DABCO in DMF: Rec. Trav. Chim., 99, 355 (1980).
• Can also be used for the masking of the imidazole ring in histidine as the 2,4-dinitrophenyl derivative during peptide synthesis, introduced in the presence of, e.g. K2CO3: Biochem. Biophys. Acta., 82, 412 (1964). The group can be cleaved by treatment with thioglycolic acid, mercaptoethanol, dithiothreitol or thiophenol: Biochem. Biophys. Res. Commun., 29, 178 (1967); Biochemistry, 9, 5122 (1970). The electron withdrawing character of the group has been shown to reduce racemization promoted by the imidazole function: J. Biol. Chem., 247, 4768 (1972). See Appendix 6.