物质信息
ID:713
名称和标识
IUPAC标准名
1-methyl-3-phenylpyrrolidine-2,5-dione
别名
Phensuximide
商标名
Fensuximida [INN-Spanish]LifeneMethylphenylsuccinimideMilontin7 PhenosuccimidePhensuximidFenosuccimidePhensuximidum [INN-Latin]PhenylsuximideN-Methyl-alpha-phenylsuccinimidePhensuximide (USP)Phensuximide [BAN:INN]Succinimide, N-methyl-2-phenyl-SuccitimalEpimid(+/-)-N-Methyl-2-phenylsuccinimide1-Methyl-3-PhenylsuccinimideFensuccimide [DCIT]Milontin (TN)N-Methyl-2-phenylsuccinimideMilontonMirontinMirotinN-Methyl-alpha-phenolsuccinimide
IUPAC传统名
N-methyl-2-phenyl succinimide
化合物性质
理化性质
溶解度
7020 mg/L
疏水性(logP)
0.7
描述信息
Drug Groups
approved
Description
Phensuximide is an anticonvulsant in the succinimide class. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.
Indication
For the treatment of epilepsy.
Pharmacology
Phensuximide suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in absence (petit mal) seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic.
Absorption
Rapid and complete.
Protein Binding
21%
References
•
Rankin GO, Cressey-Veneziano K, Wang RT, Brown PI: Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat. J Appl Toxicol. 1986 Oct;6(5):349-56.
[Pubmed]
•
CHEN G, WESTON JK, BRATTON AC Jr: Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide. Epilepsia. 1963 Mar;4:66-76.
[Pubmed]
•
Ferrendelli JA, Kinscherf DA: Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain. Ann Neurol. 1979 Jun;5(6):533-8.
[Pubmed]
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参考文献
• CHEN G, WESTON JK, BRATTON AC Jr: Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide. Epilepsia. 1963 Mar;4:66-76. Pubmed
• Ferrendelli JA, Kinscherf DA: Inhibitory effects of anticonvulsant drugs on cyclic nucleotide accumulation in brain. Ann Neurol. 1979 Jun;5(6):533-8. Pubmed
• Rankin GO, Cressey-Veneziano K, Wang RT, Brown PI: Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat. J Appl Toxicol. 1986 Oct;6(5):349-56. Pubmed