物质信息
ID:712
名称和标识
别名
TrifluoperazineTrifluoperazine HydrochlorideTrifluoroperazineTryptazine DihydrochlorideTrifluoperazinTriphthazine DihydrochlorideTrifluroperizineTrifluoroperazine DihydrochlorideTrifluoroperazine HydrochlorideTrifluoromethylperazineTrifluoperazine DihydrochlorideTrifluoperazine HClTrifluoperazinaTrifluperazine
IUPAC传统名
trifluoperazine
IUPAC标准名
10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
商标名
ModalinaNovo-TrifluzineTerfluzineTrazineTriftazinTriphtazinEskazinylStelazineStellazineTriphtazineEskazineSynklorTriftazineTriperazineTryptazineFluoperazineJatroneuralTriflurinTriphthasineTriphthazine
化合物性质
理化性质
疏水性(logP)
4.9
溶解度
0.0122 mg/mL at 24 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]
描述信息
Drug Groups
approved
Description
A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. [PubChem]
Indication
For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
Pharmacology
Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Toxicity
Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic.
Half Life
10-20 hours
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