物质信息

ID:698

名称和标识
别名
ROSRosoxacine [INN-French]RosoxacinRosoxacino [INN-Spanish]Acrosoxacin
商标名
EradacilEradacinRoxadylEracineWinuron
IUPAC标准名
1-ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid
IUPAC传统名
rosoxacin
数据登录号
PubChem CID
PubChem SID
化合物性质
理化性质
疏水性(logP)
3
溶解度
0.0209 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]
描述信息
Drug Groups
approved
Description
Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock.
Indication
For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
Pharmacology
Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Affected Organisms
Enteric bacteria and other eubacteria
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