物质信息

ID:696

MolImageID:694

Sodium lauryl sulfate

DrugBank
名称和标识
IUPAC标准名
sodium dodecyl sulfate
IUPAC传统名
potassium @dodecyl sulfate
别名
Dodecyl sodium sulfateSodium lauryl sulfateSDSSulfuric acid dodecyl ester sodium saltSodium monododecyl sulfateSodium monolauryl sulfateSodiumlauryl ether sulfateLaurylsiran sodny [czech]NADDSNALSSodium dodecyl sulfateLauyl sodium sulfateSodium lauryl sulphateN-dodecyl sulfate sodiumNatrium laurylsulfuricumSulfuric acid, monododecyl ester, sodium saltSodium lauryl sulfateDodecyl sulfate sodium saltDodecyl sulfate, sodium saltLauryl sulfate sodiumLauryl sulfate sodium saltLauryl sulfate, sodium saltMonododecyl sodium sulfateDodecyl alcohol, hydrogen sulfate, sodium saltDodecyl sulfate sodiumSodium n-dodecyl sulfateLauryl sodium sulfateNatriumlaurylsulfatSulfuric acid monododecyl ester sodium salt
商标名
Adeka Hope LS 90Alscoap LN 90Alscoap MP 90NAnticerumenAquarex methylTrepenol WAWAQESulfopon T 30Sulfopon WA1 SpecialSulfopon WA2Sulfotex walaTexapon K12Texapon ZHCSorpol 5029OStandapol 112 concStandapol WAQ specialStepanol WA pasteStepanol WA specialSulfolyserRichonol CRolpon LSRosulfan L 1Sipex ubSipon PDSipon ubNikkol SLSNissan persoft SPOrvus WA pastePolystep B 3Rhodapon LSBRichonol AFMelanol CLMelanol CL 30Monogen LHMonogen Y 100Needle 10NeutrazymeEmpicol LX 42Empicol LXVEquex SPFongrapol LSSGardinolK 12 (surfactant)Duponol waqaEmal 10 NeedleEmal 10 PowderEmal osEmersal 6400Empicol LPZConco sulfate WA-1245Cycloryl 580Cycloryl 585NDehydag sulfate GLDehydag sulfate GL emulsionDuponol QCAkyposal NLSCalfoam ES 303Carsonol SLSCarsonol SLS specialConco sulfate WA-1200Ufarol TCL 92Witcolate ASwascol 1PSwascol 3LTarapon K 12Texapon K 12Texapon L 100Texapon V HC powderStepanol ME DRY AWSterling waq-CHSterling waq-cosmeticSulfetal L 95Sulfotex WASunnol LM 1130Sipon LSBSorpol 8070Standapol WAS 100Stepanol WA 100Stepanol MEStepanol ME DRY SLSSintrex L 100Sipex SBSipex SDSipex opSipon LSSipon LS 100Rewopol NLS 30Rhodapon LCPRhodapon SMSinnopon LS 95Sinolin 90TK-NSintapon lLanette wax sLanette wax-sMonogen Y 500Nissan Sintrex L 100Odoripon Al 95Quolac ex-ubEquex SFinasol OSR 2Finasol osr(sub 2)Finasol OSR2Gardinol type detergentIriumEmal oEmpicol 0303Empicol BSD 70Empicol LS 30Empicol LX 28REmpicol LXSV 938UDuponol methylDuponol WADuponol WA DRYDuponol WAQDuponol waqeEmal 2F30Texapon K 12GTexapon K1296Texapon Z high conc. needlesStepanol WACSulfopon WA 1 SpecialSurfactant K12Surfax 220Swascol 4LTexapon DL conc.Richonol ASipon WDStandapol WA-ACSteinapol NLSSteinapol NLS 90Stepanol T 28Maprobix neuMaprofix 563Maprofix LKPerlankrol E.S.D. 60Polystep B 5Rhodapon SB 8208SEmpicol LX 28Empicol LY 28SEmpimin SDSHexamol SLSIncronol SLSJordanol SL-300Duponol waqmEmal 10Emal 2F NeedleEmpicol 0303VAEmpicol LX 2Texapon V HCUfarol AM 30Ultra sulfate SL-1Sulfopon WA3Sulfopon WA 1Supralate CSyntapon LTexapon K 1296Texapon K 1298Stepanol WA extraStepanol WAQSterling WA pasteSulfochem SLSSulfopon WA 2Sulfopon WA 3Stepanal WACStepanol WA-100Stepanol ME DRYStepanol methylStepanol methyl DRY AWStepanol WASipex SPSipon LCS 98Solsol needlesStandapol WAQStandapol WAQ-LCStanfax 234Rewopol NLS 28Rhodapon SBRhodapon UBSandet onaSilipon RN 6031Sinnopon LS 100Montopol LA pasteOrvus WAPerklankrol ESD 60Perlandrol LPerlankrol LPionin A 21Emulsogen LSGenapol LSSMaprofix neuMaprofix wacMaprofix wac-laMonagen Y 100Emal 2FEmpicol LZ/DConco sulfate WAGDehydrag sulfate GL emulsionDetergent 66DreftDuponolAkyposal SDSAlscoap LN 40AAlscoap SP 40Avirol 101Calfoam SLS 30Conco sulfate waCycloryl 21DermacideDupanol waqDuponal waqeDuponol QXDuponol MEAvirol SL 2010Berol 452Carsonol SLS-sCaswell No. 779Conco sulfate WANConco sulfate WASDehydag sulphate GL emulsionDuponalDuponol cAdeka Hope LS 35Alscoap-LN 90PAquarex meAvirol 118 concBio-Soft SDBS 60Carsonol SLS paste bConco sulfate WNCycloryl 21LSCycloryl 31
数据登录号
CAS号
151-21-3
化合物性质
理化性质
疏水性(logP)
1.60 [HANSCH,C ET AL. (1995)]
溶解度
100 mg/mL [SINGER,MM & TJEERDEMA,RS (1993)]
描述信息
Drug Groups
approved
Description
Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.
Indication
SLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.
Pharmacology
SLS is an anionic surfactant. Its amphiphilic properties make it an ideal detergent.
Toxicity
Oral (LD50): Acute: 1288 mg/kg [Rat]
Affected Organisms
Humans and other mammals
References
• Agner T: Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol. 1991;71(4):296-300. [Pubmed]
• Marrakchi S, Maibach HI: Sodium lauryl sulfate-induced irritation in the human face: regional and age-related differences. Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. [Pubmed]
• Loffler H, Effendy I: Skin susceptibility of atopic individuals. Contact Dermatitis. 1999 May;40(5):239-42. [Pubmed]
• Chahine L, Sempson N, Wagoner C: The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend Contin Educ Dent. 1997 Dec;18(12):1238-40. [Pubmed]
• Herlofson BB, Barkvoll P: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996 Jun;54(3):150-3. [Pubmed]
• Piret J, Desormeaux A, Bergeron MG: Sodium lauryl sulfate, a microbicide effective against enveloped and nonenveloped viruses. Curr Drug Targets. 2002 Feb;3(1):17-30. [Pubmed]
External Links
• [Wikipedia]
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参考文献
• Agner T: Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol. 1991;71(4):296-300. Pubmed
• Herlofson BB, Barkvoll P: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996 Jun;54(3):150-3. Pubmed
• Chahine L, Sempson N, Wagoner C: The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend Contin Educ Dent. 1997 Dec;18(12):1238-40. Pubmed
• Marrakchi S, Maibach HI: Sodium lauryl sulfate-induced irritation in the human face: regional and age-related differences. Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. Pubmed
• Loffler H, Effendy I: Skin susceptibility of atopic individuals. Contact Dermatitis. 1999 May;40(5):239-42. Pubmed
• Piret J, Desormeaux A, Bergeron MG: Sodium lauryl sulfate, a microbicide effective against enveloped and nonenveloped viruses. Curr Drug Targets. 2002 Feb;3(1):17-30. Pubmed
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