Sulfasalazine

名称和标识

商标名

W-T Sasp OralAzopyrinAzulfidine EN-TabsPMS-SulfasalazinePms-Sulfasalazine E.C.ReupirinSulcolonSalazopyrinSalicylazosulfapyridineSalisulfSalazosulfapyridineBenzosulfaSalazopyrin EN-TabsSalazosulfapyridinColo-PleonS.A.S. Enteric-500SalazopyridinAsulfidineAzopyrineAzulfidineRorasulSalazopiridazinAzlufidine EN-TabsAccucolAlti-Sulfasalazine

别名

SulfasalazineSulfasalazinSulphasalazine

IUPAC标准名

2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid

IUPAC传统名

sulfasalazine

数据登录号

CAS号

599-79-1

PubChem CID

5359476

PubChem SID

46505451

化合物性质

理化性质

疏水性(logP)

2.5

描述信息

Drug Groups

approved

Description

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)

Indication

For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.

Pharmacology

Sulfasalazine is an anti-inflammatory indicated for the treatment of ulcerative colitis and rheumatoid arthritis.

Affected Organisms

Humans and other mammals

Half Life

5-10 hours

Elimination

The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces.

Distribution

* 7.5 ± 1.6 L